2009, discovery of a new phenotype for micro organism in slender nanofluidic slits; and first detection of community protein buildings alongside DNA working with stable-point out nanopores
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, Groningen researchers present the outcomes of their attempts to generate labs more sustainable and provide tips for other labs.
Due to the fact 2000, Dekker has shifted the primary emphasis of his do the job in the direction of biophysics the place he studies the Qualities of solitary biomolecules and cells utilizing the tools of nanotechnology. This modification of field was driven by his fascination for that extraordinary functioning of biological molecular structures, and also because of the long-term viewpoint that lots of appealing discoveries is usually envisioned Within this area.[5] Existing traces of investigation in his biophysics team are during the parts of:[six]
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Our study ranges from your biophysics of DNA to synthetic cells and past. You should take a look under with the spectrum of our recent assignments.
‘To start with we checked out biological programs which has a physical look at and acted on The premise of the resources we understood. It took a number of years before we started out Performing more on the big biological troubles. I then began to call it nanobiology, a term that did not exist at time.
2011, initial in vitro measurements of transport across a single biomimetic nuclear pore complex; development of multiplexed magnetic tweezers for kilo-molecule experiments; and resolved the mechanism of homology recognition in DNA homologous recombination
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Really interesting, but that wasn’t truly the place my desire lay. I desired to pioneer And that i experienced the sensation that was not doable, because the most intriguing essential insights experienced currently been uncovered. But my discipline experienced developed several enjoyable new resources to measure particular person molecules. I made a decision that I desired to use this to biology, to have a look at it from the Actual physical point of view.’
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
‘That considerations the artificial cell, as Section of the Dutch BaSyC initiative. Craig Venter appeared best-down in Those people days and determined about 5 hundred genes which can be minimally demanded to get a operating mobile. We want to seem base-up: how do we transfer from the couple molecules to a complete biological procedure?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
Last but not least, I'll briefly sketch several of our Thoughts to discover the creating of synthetic cells, exclusively our 1st techniques to determine artificial mobile division.